Extrathalamic Modulation of Cortical Responsiveness

Abstract

The overall goal of the proposed studies is to further elucidate the mechanisms by which the brainstem noradrenergic (NA) nucleus, locus coeruleus (LC), is capable of altering forebrain electrophysiological activity. The proposed studies have the following Specific Aims: (1) To examine the relationship between the intensity of LC neuronal activity, forebrain EEG activation, and rates of NA release in neocortex and hippocampus using microdialysis; (2) To test the hypothesis that LC-induced activation of forebrain EEG is mediated by LC/NA actions on septal and basal forebrain neurons; (3) To examine, in unanesthetized monkey, the effects of activating or inactivating the LC/NA system on forebrain EEG and on dialysis measures of NA and acetylcholine release in neocortex and hippocampus. The effects on these dialysis measures of systemic adrenergic drugs that alter cognitive performance will also be determined; (4) To examine, in monkey, the effects of activating or inactivating the LC/NA system on cortical and hippocampal EEG measures and on complex, bimanual motor behavior.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1994
Accession Number
ADA284100

Entities

People

  • Stephen L. Foote

Organizations

  • University of California, San Diego

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Cells
  • Central Nervous System
  • Cognition
  • Cognitive Science
  • Electrophysiological Phenomena
  • Nervous System
  • Neurology
  • Neurons
  • Neurosciences
  • Psychiatry
  • Psychology
  • Psychophysiology
  • Surgery

Fields of Study

  • Biology
  • Psychology

Readers

  • Materials Science.
  • Neuroscience