Biochemistry and Chemotherapy of Malaria and Leishmaniasis

Abstract

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to: (1) Determine the action of the antimalarial 8-aminoquinolines on Leishmania sp., (2) To tests the effect of natural products on Leishmania sp. and to (3) Continue the mode of action studies on the nature of the inhibitory action of arachidonic on DNA polymerase.

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Document Details

Document Type
Technical Report
Publication Date
Dec 06, 1993
Accession Number
ADA284195

Entities

People

  • Linda L. Nolan

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Antimalarials
  • Biochemistry
  • Biological Products
  • Cells
  • Chemistry
  • Chemotherapy
  • Deoxyribonucleic Acids
  • Diseases And Disorders
  • Environmental Health
  • Fungi
  • Infection
  • Leishmania
  • Metabolism
  • Parasites
  • Protozoa
  • Public Health

Fields of Study

  • Medicine

Readers

  • Economics
  • Parasitology and Pharmacology of Malaria.