Mechanisms of Cytotoxicity of the Aids Virus

Abstract

Regulatory genes of HIV-1, HIV-2, and SIV are important in modulating virus infection and infection and transmission in vivo. Viral proteins R. (VPR) and X (VPX) and the negative factor (NEF) are three of the least well characterized regulatory proteins. Identification of their functions, their mechanisms of actions, and structure-function relationships of each protein, in vitro and in vivo will assist in our understanding of the pathogenesis of HIV induced disease. This information will be critical in defining therapeutic approaches to suppression HIV-1 infection, replication, and transmission. HIV, AIDS, Cytotoxicity, Biology, Biotechnology, pr, Vpx, Nef, HIV-1, Vpu

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1994
Accession Number
ADA284276

Entities

People

  • Lee Ratner

Organizations

  • University of Washington

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Cytoskeleton
  • Dna Sequence Analysis
  • Fatty Acids
  • Health Services
  • Lymphocytes
  • Polymeric Films
  • Proteins
  • Proteomics
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Enterprise Information Systems Architecture and Joint Command Capability Interoperability Support.
  • Molecular Genetics
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech