Analysis of Investigational Drugs in Biological Fluids - Method Development and Routine Assay

Abstract

Work on development and/or validation of analytical methodologies during the first half of the contract focused on assays for WR 238,605, halofantrine (and its metabolite), WR 6026 (and its metabolites), mefloquine (and its metabolite), artelinic acid, p-aminoheptanophenone (and related compounds), and primaquine (and its metabolite). Work on routine analyses of biological specimens during this period was performed for studies that required determination of concentrations of WR 238,605, halofantrine (and its metabolite) , WR 6026 (and its metabolites), mefloquine (and its metabolite), p- aminoheptanophenone (and related compounds), and primaquine (and its metabolite) . HPLC, Plasma, Blood, WR 238,605, Halofantrine, WR 6026, Mefloquine, Artelinic acid, p-aminoheptanophenone, Primaquine, Assay

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Document Details

Document Type
Technical Report
Publication Date
Aug 14, 1994
Accession Number
ADA284637

Entities

People

  • Emil T. Lin

Organizations

  • University of California, San Francisco

Tags

DTIC Thesaurus Topics

  • Blood
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromatographs
  • Ethers
  • Health Services
  • Liquid Chromatography
  • Malaria
  • Mass Spectrometry
  • Medical Personnel
  • Organic Chemistry

Fields of Study

  • Chemistry

Readers

  • Parasitology and Pharmacology of Malaria.