Noninvasive Ambulatory Assessment of Cardiac Function and Myocardial Ischemia in Healthy Subjects Exposed to Carbon Monoxide
Abstract
This study investigated the effects of carbon monoxide (CO) exposure on cardiac function during exercise. Subjects had their blood COHb level raised to 5%, 10%, 15%, and 20% COHb by inhaling air and CO mixtures from Douglas bags and by breathing air and CO chamber mixtures to maintain COHb level during exercise. AH subjects performed both multistage treadmill (to 10 METS) and hand- crank (to 5 MEETS) exercise at each CO exposure level. Sixteen subjects ranging from 21 to 29 years of age (mean of 24.6 years) completed the study. The results indicate that young, apparently healthy males can perform submaximal upper and lower-body exercise without adverse health effects after CO exposures attaining 20% COHb. The data also show that the cardiovascular system compensates for the reduced oxygen-carrying capacity of the blood by augmenting heart rate, cardiac contractility, and cardiac output for both types of exercise. The enhanced response begins to fail at higher levels of CO exposure and exercise, and although not tested in this study, must ultimately result in reduced maximal exercise capacity. Carbon monoxide, Carboxyhemoglobin, Cardiac output, Contractility, COHb
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1994
- Accession Number
- ADA286014
Entities
People
- K. Bolick
- L. Van Hoose
- M. L. Mccartney
- Milan Hazucha
- Paul N. Kizakevich
Organizations
- RTI International