Computer Based Analysis and Synthesis of Retinal Function
Abstract
A fully functional, real time dynamic model of retinal activity has been implemented on a high speed digital image processor. The model uses a complete set of physiciological parameters derived from electrophysiological studies of synaptic transmission, cell coupling, voltage-gated currents and visual function in the retina of the tiger salamander. This model displays the patterns of activity generated at each sheet of retinal cells in real time, in response to any arbitrary stimulus pattern. Recent work measures both the patterns of activity and the activity of single units within the living retina itself at the level of the photoreceptors, horizontal and bipolar cells. These measurements are then correlated with the patterns generated by the model to verify the accuracy of the parameters and functions used to model the retina. For the most part, the correlations are quite close, suggesting that the parameters we have used and the functional relations between elements we have selected are adequate. A recording system using an array of electrodes to constructed and will be used during the next year to record patterns of activity. These patterns will then be compared with those generated by the model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 27, 1994
- Accession Number
- ADA286084
Entities
People
- Frank S. Werblin
Organizations
- University of California, Berkeley