Development of Novel Models for Describing Multiple Toxicity Effects

Abstract

The objective of this study is to develop more quantitative approaches for the analysis of biological responses to mixtures of toxic materials. The work during the report period focused on developing and extending nonideal modifications to the isobole model for mixture dose-response analysis. Programs to analyze mixture data have been written and used for this purpose. They employ maximum likelihood analysis to the simultaneous determination of dose-response and interaction parameters. The use of spreadsheets to do the same computation has also been investigated, and found promising. -Mis report contains an appendix that enumerates studies from the literature containing mixture dose-response information; many of these studies have been and are currently being used in the project work.

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Document Details

Document Type
Technical Report
Publication Date
Oct 12, 1994
Accession Number
ADA286500

Entities

People

  • Charles N. Haas
  • Maurice J. Frank

Organizations

  • Drexel University

Tags

DTIC Thesaurus Topics

  • Cells
  • Chemical Synthesis
  • Chemistry
  • Data Analysis
  • Health Services
  • Malathion
  • Materials
  • Medical Personnel
  • Organic Chemistry
  • Pharmacology
  • Risk Analysis

Readers

  • Computational Modeling and Simulation
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology