Protection Against the Acute and Delayed Toxicities of Mustard and Mustard-Like Compounds.
Abstract
We are investigating the hypothesis that modalities which cause a reversible cell cycle arrest will decrease sulfur mustard toxicity by allowing more time for DNA repair before cell division takes place. Both human fibroblasts and NM-1 keratinocytes have been exposed to hypothermic conditions (280C). This temperature arrests the growth of both cell lines, but they recover rapidly on transfer back to 37 deg C. Similarly, exposure to 8 uM ciclopirox olamine produces a readily reversible cell cycle arrest. Experiments are currently in progress to determine the efficacy of these treatments in reducing sulfur mustard cytotoxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 04, 1994
- Accession Number
- ADA288431
Entities
People
- David B. Ludlum
Organizations
- University of Massachusetts