Studies of Altered Response to Infection Induced by Severe Injury.
Abstract
The Systemic Inflammatory Response Syndrome (SIRS) that frequently occurs post-injury'. is a major cause of post-trauma mortality and is characterized by both immunosuppression and cytokine aberrations. This research focuses on identifying the relative contributions of T cell and monocyte (M0) aberrations to SIRS. In the first half of the contract, we have shown that MO TNFa production (a major contributor to SIRS) is aberrantly increased in trauma patients by: 1 Failure to rapidly degrade TNFa mRNA leading to prolonged TNFa protein production: 2. Insensitivity to normal downregulation by prostaglandin E2 and TGFa; 3.Increased sensitivity' of MO to TNFa induction by LTB4; 4.Increased MO autocrine stimulation by TNFa due to stimulation through unshed TNFR: 5.Decreased production of the TNFa immunoregulatory cytokine IL-1O by patients MO and T lymphocytes: 6.Decreased T lymphocyte production of IF
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 15, 1994
- Accession Number
- ADA288907
Entities
People
- Carol L. Miller-graziano
Organizations
- University of Massachusetts