Decreased Pulmonary Damage in Primates With Inhalation Injury Treated with High-Frequency Ventilation.
Abstract
Smoke inhalation leads to a complex sequence of pulmonary and pathophysiologic events that contribute to a high morbidity and mortality when combined with thermal injury.'2 While the volume and composition of the inhaled material clearly influence the severity of the pulmonary manifestations of inhalation injury, other data suggest that the mode of ventilatory support may also affect the severity of the disease process.3 The term 'high-frequency ventilation' (HFV) describes a group of ventilatory techniques that use low tidal volumes at supraphysiologic respiratory frequencies, When used with appropriate ventilation strategies, HFV can maintain the lung at a given mean volume/ pressure with less excursions above and below the mean than can be accomplished with conventional mechanical ventilation. This, in theory, should lessen the risk of ventilator-induced lung injury. JMD
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1993
- Accession Number
- ADA289628
Entities
People
- Basil A. Pruitt
- Dale A. Gerstmann
- Jacqueline J. Coalson
- Robert A. Delemos
- William G. Cioffi
Organizations
- United States Army Institute of Surgical Research