Coupling of Brain Muscarinic Receptors to Second Messengers.

Abstract

Stimulating muscarinic acetylcholine receptors results in activation of various signal transduction pathways. The goal of the research was to investigate the selectivity of coupling of the currently known 5 subtypes of muscarinic receptors to these different second messenger pathways. Results indicate that m1, m3 and m5 muscarinic receptors are coupled to enhanced phosphoinositide hydrolysis, while m2 and m4 receptors are coupled to a decrease in cyclic AMP formation. Results also demonstrate efficient coupling of m5 muscarinic receptors to generation of nitric oxide.

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Document Details

Document Type
Technical Report
Publication Date
Oct 28, 1994
Accession Number
ADA290498

Entities

People

  • Esam E. El-fakahany

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Azo Compounds
  • Biological Sciences
  • Brain
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Couplings
  • Demographic Cohorts
  • Hydrolysis
  • Information Operations
  • Medical Personnel
  • Mrna
  • Neurosciences
  • Pharmacology
  • Scientists
  • Therapy

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  • Neurotoxicology