Cessation of Focal Epileptiform Activity Using Cortical Calcium Blocker.

Abstract

60-80 POUND MALE PIGS WERE SUBJECTED TO GENERAL ANESTHESIA, USING A BALANCED NARCOTIC TECHNIQUE (FENTANYL). The animals were then subjected to removal of the entire flat surface of the calvarium, as well as the dura (aside from the superior sagittal sinus). A cortical electroencephalographic (EEG) grid (PMT Corp.) was then placed over the surface of the exposed brain. Through a 3mm. hole in the grid, a seizure focus was established, using penicillin (5,000,000 U/cc.). Once this was definitively established, the penicillin was removed and replaced with a calcium channel blocker (nimodipine). In two out of four procedures, the focal epileptiform activity was ameliorated or altered.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1995
Accession Number
ADA291294

Entities

People

  • Leon E. Moores
  • William C. Bergman

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Anesthesia
  • Animals
  • Anti-Bacterial Agents
  • Anticonvulsants
  • Biological Sciences
  • Biomedical Research
  • Chemical Warfare Agents
  • Drug Abuse
  • Epilepsy
  • Fentanyl
  • Head Injuries
  • Laboratory Animals
  • Materials
  • Recombinant Dna
  • Seizures
  • Surgery

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology
  • Trauma Surgery or Emergency Medicine.