Role of Bone Marrow Micrometastases in Breast Cancer.
Abstract
Although most women with breast cancer present with local disease, 30-40% of these women will develop advanced disease. Several tumor characteristics have been suggested to be predictive of disease recurrence, among them the presence of micrometastatic disease In the bone marrow. The purpose of this research proposal was to determine if adjuvant therapy could alter this risk factor, that is, will standard adjuvant therapy eliminate these metastatic cells. Additionally this project was going to examine the same questions in patients who presented with metastatic disease or with metastatic disease recurrence. Unfortunately, the study was significantly handicapped by the reluctance of women to have a non-treatment related bone marrow done, even when the procedure was made available during general anesthesia. Therefore, we did not have sufficient patient accrual to fulfill our study objectives. Our data would suggest, however, that the incidence of bone marrow micrometastases is not as frequency as suggested by some authors in the literature.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 22, 1994
- Accession Number
- ADA293749
Entities
People
- Katherine H. Moore
- Kenneth A. Bertram
- Mark Brissette
Organizations
- Madigan Army Medical Center