Host Factors Contributing to Disability Following Sulfur Mustard Exposure.

Abstract

Cytokines in SM lesions. We demonstrated the mRNAs of four major cytokines in developing and healing rabbit SM lesions: Interleukin 1 (beta), (IL-1 (beta)), neutrophil attractant/activation protein-i (NAP-1 or IL-8), monocyte chemoattractant (activating) protein 1 (MCP-1), and the chemokine GRO (a growth factor and chemoattractant for granulocytes). The macrophages and activated fibroblasts in the lesions contained the mRNA of all four cytokines, with the highest amounts in the peak lesions and decreased amounts during healing. Granul ocytes contained the mRNA of IL-1 (beta) and NAP-1. In the epithel ial cells of hair follicles, GRO mRNA was up-regulated as early as 1 hour after the the application of sulfur mustard and remained high during the healing process. In SM lesions (but not in normal skin), surface epithelial cells and/or hair follicle epithelial cells contained the mRNA of NAP-1, MCP-1 and GRO.

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Document Details

Document Type
Technical Report
Publication Date
Jan 31, 1995
Accession Number
ADA294497

Entities

People

  • Arthur M. Dannenberg Jr.

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Blood
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Granulocytes
  • Lymphocytes
  • Macrophages
  • Medical Personnel
  • Organic Chemistry
  • Proteins

Fields of Study

  • Medicine

Readers

  • Geochemistry
  • Immunology and Pathology