Inhibition of Rabbit Sperm Cell Hyperactivated Motility by Metallic Ions in Toxicological Testing.

Abstract

Rabbit sperm cells developed hyperactivated motility when incubated in medium N. Hyperactivated but not normal progressive motility was inhibited by lead and cadmium, two metals implicated in fertility dysfunction. A metal of military interest, Cr+6, had a similar outcome on rabbit sperm, suggesting that it may also have the same property as cadmium and lead. Two metals, zinc and mercury, without fertility effects did not suppress hyperactivated motility. The rabbit sperm-medium M-hyperactivated motility system may have a role in the in vitro assessment of the antifertility effects of chemicals.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1995
Accession Number
ADA294504

Entities

People

  • Dale H. Heitkamp
  • Ronald J. Young

Organizations

  • Edgewood Chemical Biological Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Albumins
  • Animals
  • Biological Sciences
  • Cell Movement
  • Cells
  • Chemistry
  • Contrast
  • Engineering
  • Fertility
  • Incubation
  • Inhibition
  • Intervals
  • Laboratory Animals
  • Materials
  • Metals
  • Microscopes
  • Time Intervals

Readers

  • Analytical Chemistry
  • Surface Engineering/Surface Coating Technology.
  • Toxicology/Environmental Toxicology