Early Detection of Breast Cancer and Recurrence Following Therapy with Magnetic Resonance Imaging and Spectroscopy.
Abstract
The major hypothesis of this project is that use of a combination of Magnetic Resonance Imaging (MRI), MRI with contrast, magnetization transfer contrast and proton Magnetic Resonance spectroscopy (MRS) will lead to improved detection and characterization of breast cancer. At present mammography detects lesions which have about an 80% false positive rate for malignancy. There are strong preliminary indications that the combination of MRI with dynamic contrast uptake studies can both detect lesions and provide improved characterization over mammography. The addition of the metabolically based MRS parameters into an approach based on multivariate classification should improve the characterization even further. Technical progress has been made in three areas: the development of a breast array for bilateral imaging of the breast, the development of B1 mapping methods and improvements in the use of multicoil MRS. In the second year of this study. additionai measurements have been obtained on: 25 patients undergoing breast-conserving surgery and definitive breast irradiation for treatment of early stage breast cancer; 18 patients undergoing breast biopsy for suspicious breast abnormalities, but without a confirmed diagnosis of malignancy; and 2 patient with locally advanced breast cancer. (AN)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1995
- Accession Number
- ADA294542
Entities
People
- Lawrence Solin
- Robert E. Lenkinski
Organizations
- University of Pennsylvania