Pyridostigmine Synergistic Toxicity Study.

Abstract

This study investigated the lethal interaction of pyridostigmine bromide (PB), permethrin, and DEEr when given to adult male rats by gavage. The study was separated into two phases. The first (Phase I) determined the acute oral lethal dose-response relationship of each compound with the vehicle, propylene glycol. The second (Phase II) was divided into two portions. One portion (positive control) was a dose-response study using probit units obtained from phase I (LD 16. 30, 50, 70, and S4). Dosage solutions for the second (interaction) portion of phase II contained the calculated LDl6 (additive l,D16) of two compounds while the concentration of the third compound was varied.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
May 31, 1995
Accession Number
ADA295869

Entities

People

  • Wilfred C. Mccain

Organizations

  • United States Army Center for Health Promotion and Preventive Medicine

Tags

DTIC Thesaurus Topics

  • Additives (Chemicals)
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Dermatologic Agents
  • Environmental Protection
  • Factor Analysis
  • Glycols
  • Lethal Dosage
  • Lethality
  • Liquid Chromatography
  • Pesticides
  • Propenes
  • Propylene Glycol
  • Pyridostigmine Bromide
  • Statistical Analysis
  • Toxicity

Readers

  • Electrical Engineering
  • Toxicology/Environmental Toxicology