Vaccination Against Cholesterol: Immunologic Modulation of Diet-Induced Hypercholesterolemia and Atherosclerosis in Rabbits.
Abstract
Immunization of rabbits with a protein-ftee formulation consisting of liposomes containing 71% cholesterol and lipid A as an adjuvant induced antibodies that recognized highly purified nonoxidized crystalline cholesterol and rabbit VLD/IDl by ELISA. In rabbits that were fed an atherogenic diet containing O.5%-l.O% cholesterol, a marked diminution of hypercholesterolemia (as much as 979 mg/dl lower) was observed in the immunized animals when compared to nonimmunized controls. Analysis of aortic fatty streaks by automated morphometric probability-of-occurrence mapping of audanophilia showed significantly diminished lesions in vaccines in most areas of the aorta.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1995
- Accession Number
- ADA296108
Entities
People
- Carl R. Alving
- Edward E. Herderick
- Glenn M. Swartz Jr.
- Nabila M. Wasssef
- Renu Virmani
Organizations
- Walter Reed Army Institute of Research