Insulin-Like Growth Factor II as a Prognostic Indicator in Breast Cancer.

Abstract

Insulin-like growth factor II is a potent mitogen for breast tumor epithelium. The purpose of this study is to analyze IGF-II expression in a series of breast tumor biopsy specimens and determine whether IGF-II expression relates to clinical indicators and outcome. We have processed over 300 cases by in situ hybridization and immunohistochemistry. Of 240 cases scored so far, IGF-II protein expression was absent in 16%, low in 23%, moderate in 43% and high in 18%. These data correlate well with the data obtained by in situ hybridization. Preliminary correlation with clinical parameters and outcome shows that IGF-II expression may be associated with poor prognosis in patients who are negative for estrogen and progesterone receptor.

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Document Details

Document Type
Technical Report
Publication Date
Jan 14, 1995
Accession Number
ADA296358

Entities

People

  • Kevin J. Cullen

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cells
  • Chemistry
  • Epithelial Cells
  • Estrogens
  • Growth Factors
  • Hybridization
  • Immunohistochemistry
  • Materials
  • Neoplasms
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Statistical Analysis

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology and Biomarker-Based Cancer Detection.