Drug Assessment Plan for the Evaluation of Antivesicant Pretreatment and Treatment Compounds.
Abstract
The Antivesicant PIT Plan is designed to rapidly identify compounds which, when given orally or parenterally before or shortly after vesicant exposure, will be effective in the prevention or reduction of vesicant-induced cutaneous injury. Antivesicant compounds. are being considered for both pretreatment and treatment modalities. Pretreatment refers to the administration of compound before exposure to vesicants, whereas treatment refers to the administration of compound after exposure but before the onset of incapacitating signs. In both Cases, the aim is to prevent or reduce the lesions associated with vesicating agents. This plan is not designed to identify compounds which, when given after the development of lesions, will speed healing of those lesions. Ideally, both pretreatments and treatments should be void of undesirable side effects since administration of the drugs would occur before the onset of incapacitating lesions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1995
- Accession Number
- ADA296520
Entities
People
- E. T. Clayson
- H. L. Meier
- J. A. Romano Jr
Organizations
- United States Army Medical Research Institute of Chemical Defense