Custom Tailoring Therapy for Breast Cancer Using erbB-2.

Abstract

Since erbB-2 failed to be a therapeutic response variable for tamoxifen response, we have used gene trap U3lacZ to clone estrogen regulated molecules in breast cancer cells. Bcl-2 gene was identified as an estrogen inducible gene. A novel estrogen repressed gene was cloned. Their potential role as therapeutic response variable is being examined. NSABP B-11 was examined for erbB-2 expression. Statistical analysis of the B-11 is pending.

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Document Details

Document Type
Technical Report
Publication Date
Jun 05, 1995
Accession Number
ADA298302

Entities

People

  • Soonmyoung Paik

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Alkenes
  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Epithelial Cells
  • Estrogens
  • Laboratory Animals
  • Mammary Glands
  • Materials
  • Molecules
  • Neoplasms
  • Recombinant Dna
  • Statistical Analysis

Readers

  • Molecular Biology and Genetics
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.