Trichloroethylene: Metabolism and Other Biological Determinants of Mouse Liver Tumors

Abstract

Trichioroethylene (TCE) is one of the most commonly found groundwater contaminants at DoD facilities due to its widespread use in degreasing and as a solvent in other operations. Trichioroethylene has been the subject of extensive study including a large number of lifetime studies in laboratory rodents exposed by inhalation and oil gavage (oral bolus dosing). Several toxicities have been identified, including both noncarcinogenic and carcinogenic effects. This review considers both pharmacokinetic and pharmacodynamic factors that could act as determinants of TCE carcinogenesis. The implications of these data are to suggest that alternatives to the current risk assessment for TCE-induced cancer should be seriously considered.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1994
Accession Number
ADA298874

Entities

People

  • B. M. Jarnot
  • H. A. Barton
  • J. C. Lipscomb
  • J. Z. Byczkowski
  • S. R. Channel

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Fatty Acids
  • Laboratory Animals
  • Organic Chemistry

Fields of Study

  • Medicine

Readers

  • Groundwater Contamination Remediation.
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology