Gas Uptake Kinetics of Bromotrifluoromethane (Halon 1301) and Its Proposed Replacement Iodotrifluoromethane (CF3I).
Abstract
A physiologically based simulation approach was used to estimate in vivo metabolic constants in male Fischer 344 rats for the two chemicals, bromotrifluoromethane (Halon 1301), and its proposed replacement candidate, iodotrifluoromethane (CF3I). A closed recirculating exposure system was used to collect a series of gas uptake curves for both chemicals at equivalent initial exposure concentrations. Additionally, tissue:air partitiOn coefficients were determined experimentally for each chemical and incorporated into a physiologically based pharmacokinetic model, which was then used to simulate the uptake of the chemicals. By iteratively adjusting the constants describing metabolism of the chemical, and optimized fit of the series of uptake curves was obtained for each chemical. This simulation approach adequately described the overall uptake of each chemical from the chamber. Given the relatively low level of partitioning of these chemicals into tissues and their relative inertness, this approach could not be used with certainty to discriminate between metabolism by saturable and/or first-order process and no metabolism at all.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1994
- Accession Number
- ADA299031
Entities
People
- G. W. Jepson
- J. R. Creech
- R. J. Williams
- R. K. Black
- S. K. Neurath