An Organophosphorus Pesticide, Chlorpyrifos, Increases the Levels of the Multidrug-Resistant Gene Product in Breast Cancer Cells.

Abstract

We originally proposed that chlorpyrifos, the widely used organophosphorus pesticide, induces the expression of the multidrug resistance (mdr) gene product in a manner similar to that of chemotherapeutic agents and may contribute to a MDR phenotype seen in untreated and relapsed breast cancer patients.

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Document Details

Document Type
Technical Report
Publication Date
Jul 28, 1995
Accession Number
ADA299497

Entities

People

  • Christine Lanning
  • Robert Fine

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Availability
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Culture Techniques
  • Laser Dyes
  • Membrane Proteins
  • Membranes
  • Neoplasms
  • North Carolina
  • Pesticides
  • Proteins
  • Sodium Azides
  • Sodium Compounds
  • Tumor Cell Line
  • Vitamin C

Readers

  • Neurotoxicology
  • Oncology (Cancer Research).