Three-Dimensional Structure Determination of Botulinum toxin.

Abstract

The immediate goals on structure and function relationship studies of botulinum neurotoxin are: (1) Determine the three-dimensional structures of botulinum neurotoxins isolated Heavy chain, Light chain and holo-neurotoxin at atomic resolution by x-ray crystallography. (2) Based on the structure of the isolated chains and holo-neurotoxin, understand the toxins mechanism of action.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1995
Accession Number
ADA299771

Entities

People

  • Raymond C. Stevens

Organizations

  • University of California, Berkeley

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • California
  • Chemistry
  • Crystal Growth
  • Crystal Structure
  • Crystallography
  • Crystals
  • Diffraction
  • Electron Density
  • Health Services
  • Materials
  • Medical Personnel
  • Plastic Explosives
  • Surface Plasmon Resonance
  • Three Dimensional
  • X-Ray Diffraction

Fields of Study

  • Chemistry

Readers

  • Materials Science and Engineering.
  • Microbial Pathology