A Medical Research and Evaluation Facility (MREF) and Studies Supporting the Medical Chemical Defense Program. Determination of the Minimum Effective Pyridostigmine Pretreatment Dose in Monkeys Challenged with 5 X LD50 Soman and Treated with Atropine/2-Pam.

Abstract

This task was conducted to determine the minimum dose of pyridostigmine (PYR), and the associated level of erythrocyte acetycholinesterase inhibition (AChE-I), that provides protection from 5 X 48-br GD LD50 of untreated monkeys. Monkeys were injected im with GD and treated with 0.4 mg atropine (ATR) free base and 25.7 mg pralidoxime (2-PAM) per kg BW.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1995
Accession Number
ADA299787

Entities

People

  • Carl T. Olson
  • M. C. Matthews
  • Robyn C. Kiser
  • Ronald G. Menton
  • Timothy L. Hayes

Organizations

  • Battelle Memorial Institute

Tags

DTIC Thesaurus Topics

  • Chemical Analysis
  • Chemical Synthesis
  • Chemistry
  • Eye Diseases
  • Health Services
  • Information Science
  • Laboratory Animals
  • Liquid Chromatography
  • Medical Personnel
  • Peripheral Nervous System
  • Skeletal Muscle

Fields of Study

  • Chemistry

Readers

  • Toxicology/Environmental Toxicology