Mismatch Negativity (MMN) Indexes Subclinical Neurological Differences in HIV Patients during Rapid Perceptual Processing.

Abstract

Thirteen asymptomatic HIV-infected (HIV+) and 13 healthy control (HIV-) subjects were instructed to detect 'oddball'; target tones from among a sequence of nontarget tones delivered rapidly (3 tones/sec) in one ear while ignoring a similar sequence delivered simultaneously in the opposite ear. Event-related potentials (ERPs) to all stimuli were recorded from midline scalp sites. Both groups produced ERP correlates, termed the mismatch negativity (MMN), to the oddball tones during delivery. However, the HIV+ group produced MMNs that were different in morphology to the HIV- group, suggesting that HIV may alter attentional perceptual processing. These results suggested that auditory ERPs elicited by rapid, dichotic stimulus presentations may be useful tools in monitoring subclinical effects of HIV-related neuropathology on perceptual processing.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1995
Accession Number
ADA299924

Entities

People

  • F. S. Elliott
  • Steven E. Linnville

Organizations

  • Naval Health Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amplitude
  • Biomedical Research
  • Central Nervous System
  • Data Analysis
  • Diseases And Disorders
  • Frequency
  • Head (Anatomy)
  • Hiv Infections
  • Infection
  • Information Processing
  • Information Science
  • Marine Corps Personnel
  • Medical Personnel
  • Military Personnel
  • Monitoring
  • Naval Personnel
  • Statistical Analysis

Fields of Study

  • Biology
  • Psychology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Immunology