The Role of HAP Kinases in Breast Cancer.

Abstract

We have characterized a mammalian signal transduction pathway which is activated by TNF and IL-1, two cytokines which can inhibit the growth of some mammary tumor lines. This pathway uses a subfamily of the ERKs, the stress-activated protein kinases (SAPKs). SAPKs are the dominant kinases responsible for activation of the transactivation function of the transcription factor c-Jun. As such, the SAPKs relay TNF signals to the cell nucleus, thereby regulating gene expression in response to TNF.

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Document Details

Document Type
Technical Report
Publication Date
Aug 29, 1995
Accession Number
ADA300037

Entities

People

  • John M. Kyriakis

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Availability
  • Biomedical Research
  • Breast Cancer
  • Cell Physiological Processes
  • Cells
  • Chemical Compounds
  • Classification
  • Families (Human)
  • Identification
  • Laboratory Animals
  • Materials
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Proteins
  • Recombinant Dna

Readers

  • Breast cancer cell signaling and growth regulation.