The Role of Cyclin Dl Overexpression in Breast Cancer Progression
Abstract
The purpose of this grant is to examine the role of the cyclin DI gene, and related genes, in multistage breast carcinogenesis. These studies may provide new biomarkers and suggest novel strategies for the prevention and treatment of breast cancer. During the past year two studies were completed. The first, which is in press in Cardiogenesis indicates that carcinogen-induced rat breast tumors display dysregulation in the expression of cyclins Di and E. Since similar changes are seen in human breast cancers, the rat model may be useful for studying the role of dysregulated expression of these cyclin genes in breast cancer progression and prevention. The second study, which was recently published in Oncogene, indicates that overexpression of cyclin Di in human mammary cells can inhibit rather than stimulate cell growth. The underlying mechanisms and the implications of these findings are the subjects of current studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 14, 1995
- Accession Number
- ADA300284
Entities
People
- I. B. Weinstein
Organizations
- Texas State University