Cell-Matrix Interactions in Breast Cancer Cells.
Abstract
During the report period we have shown that breast epithelial cells attach to connective tissue via specialized matrix connectors called hemidesmosomes. The latter are lost, as are many of their components, in invasive breast tumor cells. Primary breast epithelial cells assemble hemidesmosomes in vitro. The assembly of hemidesmosomes in such cells is enhanced when they. are maintained on matrix secreted by the breast line MCFlOa. Our results emphasize the importance of matrix components in assembly of hemidesmosomes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 17, 1995
- Accession Number
- ADA300395
Entities
People
- Jonathan Jones
Organizations
- Northwestern University