Role of the Int-3 Oncogene in Mammary Gland Development and Tumorigenesis.

Abstract

Mutational activation of the murine int-3 oncogene can contribute to mammary gland tumorigenesis. Evidence suggests that int-3 regulates the morphogenesis and functional differentiation of the mouse mammary gland. The proposed research investigates the role of int-3 proteins in the normal physiology of breast development and the biochemical properties critical for int-3 transforming activity.

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Document Details

Document Type
Technical Report
Publication Date
Sep 12, 1995
Accession Number
ADA300589

Entities

People

  • Hendrik Uyttendaele
  • Jan Kitajewski

Organizations

  • Columbia University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Coding
  • Epithelial Cells
  • Genetic Structures
  • Growth Factors
  • Mammary Glands
  • Neoplasms
  • New York
  • Peptide Growth Factors
  • Proteins
  • Stem Cells

Readers

  • Microbial Pathology
  • Molecular Biology and Genetics