Statistical Genetic Methods for Localizing Multiple Breast Cancer Genes.

Abstract

Genetic risks are often computed as a single number (a so-called point estimate) under the assumption that all parameters involved in the calculation of the risk are known without error. In previous work, a method was developed to allow for variability in these parameters. Technically, by the use of the maximum likelihood method, a support interval (approximate confidence interval) is constructed for the risk. This method has been extended to incorporate age-dependent penetrances in the calculation of risk support intervals. As an empirical example, the support interval for the risk is calculated for a member of a published breast-ovarian cancer kindred.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1995
Accession Number
ADA301699

Entities

People

  • Jurg Ott

Organizations

  • Columbia University

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Accuracy
  • Availability
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Classification
  • Diseases And Disorders
  • Genes
  • Genetics
  • Genotypes
  • Intervals
  • Materials
  • Neoplasms
  • New York
  • Ovarian Cancer
  • Recombinant Dna

Fields of Study

  • Mathematics

Readers

  • Molecular and genetic basis of cancer.
  • Regression Analysis.

Technology Areas

  • Biotechnology