Biochemistry and Chemotherapy of Malaria and Leishmaniasis.
Abstract
Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease are either ineffective or toxic. Malaria is considered to be the most important infectious disease of humans on a world-wide scale. It is estimated that 300 million persons are infected at any one time in the world. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis and malaria. The objective of this research was to: (1) Determine the action of the antimalarial 8-aminoquinolines on Leishmania sp., (2) To identify and characterize unique DNA synthetic enzymes for the purpose of chemotherapeutic exploitation and (3) To test potential compounds sent by WRAIR and others for anti parasitic activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1994
- Accession Number
- ADA302242
Entities
People
- Linda Nolan
Organizations
- University of Massachusetts Amherst