Breast Tumorigenesis: Interaction of Two Signaling Pathways -- TGR-Beta Versus Estrogen Receptor.

Abstract

The goal of this research project is to explore the role of TGF-B receptors in mammary tumorigenesis and to define the relationship between estrogen receptor and TGF-B receptor signal transduction pathways. We have pursued three approaches in addressing this question: (1) reintroduction 0 - the type II TGF-B receptor into MCF-7 cells resulting in reduced tumorigeicity, (2)characterization of the role p15 and p2i, two CdkI's,play in TG -B diated signal transduction and (3) the involvement of dwarfins in the signaling cascade downstream of the TGF-B receptors. Further analysis of - the inhibitors and dwarfins will not only contribute to our understanding breast tumorigenesis, but may reveal potential targets for therapeutic intervention.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1995
Accession Number
ADA302267

Entities

People

  • Jonathan Yingling
  • Kiao-fan Wang

Organizations

  • Duke University Hospital

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Colon Cancer
  • Epithelial Cells
  • Estrogens
  • Genetic Structures
  • Growth Factors
  • Inhibitors
  • Molecules
  • Neoplasms
  • Peptide Growth Factors
  • Tumor Cell Line

Fields of Study

  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.