The Role of Protein Kinase-C in Breast Cancer Invasion and Metastasis.

Abstract

We have determined by western blot analysis the level of expression of a number of isoforms of Protein Kinase C in a panel of breast cancer cell lines of differing invasive and metastatic potential. The cells were found to express no PKC- beta, similar levels of PKC- iota lamba and various levels of PKCs 5, E and a. Of these, PKC-alpa expression levels, particularly those of the small, active form of the enzyme, were found to correlate with invasive and metastatic behavior. These findings strengthen the hypothesis that the expression of particular isoforms is associated with invasive and metastatic behavior.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1995
Accession Number
ADA302283

Entities

People

  • Michael D. Johnson

Organizations

  • George Washington University

Tags

DTIC Thesaurus Topics

  • Albumins
  • Biomedical Research
  • Blood
  • Blood Vessels
  • Breast Cancer
  • Cancer
  • Cardiovascular System
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Endothelial Cells
  • Materials
  • Membranes
  • Metastasis
  • Neoplasms
  • Ribonucleic Acids

Fields of Study

  • Biology

Readers

  • Analytical Mechanics
  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).