Modulation of Molecular Markers by CLA.
Abstract
Conjugated linoleic acid (CLA) is a naturally occurring component of the food supply that has been shown to inhibit the development of experimentally-induced breast cancer. One reported explanation for this protective activity against carcinogenesis is that ClA is an antioxidant. Studies were completed during the current reporting period that indicate that CIA does reduce lipid peroxidation levels measured as malondialdehyde in mammary tissue, which is predominantly comprised of neutral lipid, but not in liver membrane phospholipid. CIA supplementation failed to alter tissue concentrations of 8-hydroxydeoxyguanosine (8-HdG), an indicator of oxidative DNA base damage, irrespective of its effect on tissue malondialdehyde levels. These observations were made under conditions of constitutive as well as induced oxidative stress. Collectively, these data indicate that the cancer inhibitory activity of CIA is unlikely to be due to its antioxidant activity. Given these observations we are now focusing our efforts on determining the effects of CIA on mammary gland development and the pathogenetically definable events leading to the genesis of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1995
- Accession Number
- ADA302368
Entities
People
- Henry J. Thompson