The Role of Matrilysin, a Matrix Metalloproteinase, in Mammary Tumorigenesis.
Abstract
Due to the localization of matrix metalloproteinases (MMPs) in numerous human breast tumors, these proteins have been hypothesized to be involved in development and progression of breast cancer. We propose that matrilysin, an epithelial specific MMP, is partly responsible for the remodelling of the extracellular matrix during mammary development and tumorigenesis. To test our hypothesis, transgenic mice have been generated that overexpress matrilysin in mammary epithelial cells. Preliminary data indicates that overexpression of matrilysin induces excess branching during mammary development. Induction of mammary tumors are currently in progress. These studies will help address whether matrilysin plays a role in mammary tumorigenesis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1995
- Accession Number
- ADA302428
Entities
People
- Laura Rudolph
- Lynn Matrisian
Organizations
- Vanderbilt University Medical Center