Vaccines to Breast Cancer Based on P53 Mutants.
Abstract
The most commonly found molecular abnormality in human malignancies, (including mammary adenocarcinoma,) are well-defined point mutations of p53 that cluster in mutational hotspots and affect the ability of the protein to bind to DNA. Single amino acid exchanges of a self protein can break tolerance and result in activation of a specific T-cell response. In our application we proposed to test the ability of various p53 mutations using a variety of different vaccine constructs. In the first year of our application we concentrated on generating several different vaccine expressing p53 mutations. In addition, we explored different avenues in order to establish a tumor model for defined p53 mutations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1995
- Accession Number
- ADA302429
Entities
People
- Hildegund C. Ertl
Organizations
- University of Pennsylvania