The Tumor Suppressor Protein p53 and its Physiological Splicing Variant p53as in a Mouse Mammary Cancer Model.
Abstract
The proposed studies seek to explore cellular and molecular aspects of p53 function that may contribute to the development and progression of breast cancer. The hypotheses are: (1) that p53 and a novel physiological splicing variant, p53as, have distinct stability in cells, distinct expression during the cell cycle, and distinct associated proteins; (2) that p53as has different specificity or affinity for DNA binding sequences than p53; and (3) that p53 and p53as mRNA and protein are differentially expressed in mouse mammary preneoplastic and neoplastic cells and tissues with implications for breast cancer detection, prognosis or treatment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1995
- Accession Number
- ADA303189
Entities
People
- Molly Kulesz-martin
Organizations
- Health Research, Incorporated