Linkage of Molecular and Epidemiological Breast Cancer Investigations with Treatment Data: A Specialized Registry.
Abstract
During year one of this project, Cancer and Leukemia Group B (CALGB) wrote the extensive self-administered questionnaire comprising an essential element of protocol 9484 and circulated the protocol to its member institutions. At sixteen institutions the necessary Investigational Review Board (IRB) approval has been granted. Approval at the majority of the remaining 188 is anticipated shortly. After extensive pilot testing of early drafts of the questionnaires on healthy women and breast cancer patients, the telephone interview questionnaire has been perfected, the telephone interviewer hired and trained, an "800" number established, and the necessary pathways for the correlation of the phone interview information with clinical and laboratory data have been developed. The DNA extractor has been purchased, installed and tested, and the flow of patient samples from CALGB 9484 has started. Although it has taken longer than anticipated to reach a consensus and appropriate methodologies to resolve the ethical issues arising from studies of heritable cancer genes, the thorough approach taken during the current year will yield more rapid progress inm year two of the project.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1995
- Accession Number
- ADA303195
Entities
People
- O. R. Mcintyre
Organizations
- Dartmouth College