Rapid 4D MRI of Gad-DTPA Enhancement for Breast Lesion Characterization.
Abstract
The objectives of this project are refinement and clinical application of new methods designed to defeat the tradeoff between spatial resolution, temporal resolution and acquisition volume in dynamic gadolinium-enhanced MR mammography. The approach, referred to as '3D keyhole' involves specialized software for data acquisition and reconstruction that allow dynamic scans of 32 sections through both breasts to be acquired at l3second temporal resolution. This methodology provides greater precision in numerical fitting of temporal enhancement features of lesions. Extensive data processing tools have been developed to visualize dynamic contrast changes and reduce lesion temporal enhancement curves to fitted time and amplitude constants. This methodology is being applied in a prospective 4 year study of 100 women in whom a breast abnormality, detected by conventional means, is to be characterized by surgical biopsy. The targeted patient accrual in of 25 patients per year has been achieved. The hypothesized trend for malignancies to display rapid/strong contrast enhancement due to angiogenesis is apparent, although, some false positives and negatives do persist.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1995
- Accession Number
- ADA303471
Entities
People
- Thomas L. Chenevert
Organizations
- University of Michigan