Hormones and Breast Cancer.
Abstract
Grant consists of separate projects; The first aims at assessing the association between lifestyle factors (hormone use) and breast cancer; the second aims at elucidating the role of estrogen metabolism in the development of breast cancer; the third aims at understanding the relation of female hormone levels to changes in mammographic densities, a possible intermediate endpoint in cancer prevention studies. The first project uses data from a case-control study of Asian-American immigrants where the relative risks associated with oral contraceptive use will be assessed. The second project consists of two studies; a case-control study of postmenopausal breast cancer patients and a case-control study of premenopausal women with 'high' and 'normal' risk of breast cancer. Urinary estrogen metabolites will be compared to test the hypothesis that the 16-alpha pathway of estrone metabolism is associated with breast cancer risk. Project 3 is 2 studies of hormone induced changes in mammographic densities. These studies will test the hypothesis that reducing serum estrogen and progesterone levels reduces mammographic densities.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1995
- Accession Number
- ADA303738
Entities
People
- Giske Ursin
Organizations
- University of Southern California