Estrogen Metabolism in Breast Cancer Cases and Controls.

Abstract

It has been suggested that women who metabolize a larger proportion of their natural estrogen via the 16a-hydroxy pathway may be at significantly elevated risk of breast cancer compared to women who metabolize proportionally more estrogen via the 2-hydroxy pathway. This study evaluates whether the ratios of 16a-OHEl to 2-OHEl are higher in urine of postmenopausal breast cancer cases than in controls; and whether the ratio is elevated in cases independent of total urinary estrone (E1), estradiol (E2) and estriol (E3). Early morning urine samples are collected from 100 breast cancer cases and 100 controls who are participating in an ongoing case-control study of breast cancer at our institution. Five estrogen metabolites in urine are determined: 16a-OHEl, 2-OHEl, El, E2 and E3 conjugates. The data collection is in progress.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1995
Accession Number
ADA303828

Entities

People

  • Giske Ursin

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Anesthesia
  • Biological Sciences
  • Breast Cancer
  • Chemistry
  • Diseases And Disorders
  • Estrogens
  • Excretion
  • Health Services
  • Hormones
  • Materials
  • Metabolism
  • Metabolites
  • Neoplasms
  • Sex Hormones
  • Solid Phases
  • Statistical Analysis

Readers

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