Genetic Toxicity Evaluation of 1,3,3-Trinitroazetidine. Volume 2. Results of Mouse Bone Marrow Micronucleus Test.

Abstract

1 3,3-Trinitroazetidine (TNAZ) was dissolved in corn oil and injected intraperitonealy daily into albino Swiss mice for 3 days at doses of 40, 20, 10, 5, and 1 mg/kg. TNAZ did not induce an increased number of micronucleated cells and is considered to have a negative response. The positive control substance, mitomycin C, induced a statistically significant number of micronucleated cells, whereas the negative control substance (corn oil), did not induce increased number of micronucleated cells in the maturing erythrocytes of mouse bone marrow cells. Therefore, TNAZ is considered non-mutagenic, under the test system and conditions employed in this study.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1994
Accession Number
ADA303835

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  • Inder J. Paika

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DTIC Thesaurus Topics

  • Air Force
  • Blood
  • Blood Cells
  • Bone Marrow
  • Bone Marrow Cells
  • Bones
  • Cells
  • Erythrocytes
  • Governments
  • Health Services
  • Laboratory Animals
  • Medical Personnel
  • Oils
  • Plant Oils
  • Public Health
  • Range Finding
  • Toxicity

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  • Aerospace Engineering
  • Toxicology/Environmental Toxicology

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  • Biotechnology