Cellular Analysis of the Startle Reflex (FY91 AASERT).
Abstract
During the last two years we have be evaluating the role of the olivary cochlear bundle in some of these effects. We have found that local infusion into the olivary complex of lidocaine, a local anesthetic, leads to an increase in the amplitude of the compound action potential generated by an auditory stimulus recorded at the level of the cochlear nucleus. This suggests that the olivary cochlear bundle tonically inhibits auditory transmission at the level of the hair cells. Conversely, local application of kainate acid, which at very low doses activates cells, leads to a decrease in the compound action potential, consistent with an inhibitory role of the olivary cochlear system. Other drugs, such as pentazozine, that are known to act at the level of the outer hair cells, have opposite effects on the compound action potential in animals with an intact vs. a transected olivary cochlear bundle.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1996
- Accession Number
- ADA304357
Entities
People
- Michael S. Davis
Organizations
- Yale University