Environmental Risk Assessments Based on Bone Marrow Cell Kinetic.

Abstract

Risk of acute mortality from ionizing radiations, leukemia, and cancer are modeled for exposures to X-rays, photons, fission-produced neutrons, and neutrons produced by thermonuclear processes. Risks from protracted exposures are evaluated in terms of sublethal injury to cells, repair of sublethal injury, I-hit cell killing, killing of cells having unrepaired sublethal injury, and radiation-induced cellular repopulation. These cellular effects can be used to equate the protracted exposure to a prompt or pulse exposure of a reference radiation such as through a calculated value for the Equivalent Prompt Dose (EPD). Model coefficients are given for hematopoietic stem cells, marrow stromal cells, and four representative line of human leukemia and lymphoma cells. A user-friendly, menu-driven, personal computer executable file named MarCell (for marrow cell) is included with this report.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1996
Accession Number
ADA304581

Entities

People

  • Jafar S. Hasan
  • Max D. Morris
  • Troyce D. Jones

Organizations

  • Oak Ridge National Laboratory

Tags

DTIC Thesaurus Topics

  • Bone Marrow Cells
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Databases
  • Gamma Rays
  • Health Services
  • Hemorrhage
  • Lymphocytes
  • Neoplasms
  • Radiation Sickness
  • Rodents
  • Stem Cells

Fields of Study

  • Physics

Readers

  • Immunology and Pathology
  • Molecular Biology and Genetics
  • Nuclear and Radiation Engineering.

Technology Areas

  • Biotechnology