Genetic Evidence of Early Breast Cancer.
Abstract
The earliest phases of breast cancer are poorly characterized. A precise understanding of the genetic changes which herald incipient transformation would be invaluable for accurate early diagnosis and a better understanding of its pathogenesis. Towards this goal, we aim to identify clonal breast populations based on the detection of only one X-chromosome androgen receptor allele after differential methylation sensitive restriction enzyme digestion. Although this analysis is suitable for large amounts of DNA, it was not reliable when small cell numbers were analyzed. Since the earliest breast cancer lesions are small, we have yet to develop a suitable assay for their analysis. However, new efforts based on technical improvements show promise for both high sensitivity and reliability.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1995
- Accession Number
- ADA305889
Entities
People
- Darryl Shibata
Organizations
- University of Southern California