Estrogen Metabolism and Familial Risk of Breast Cancer.

Abstract

It has been suggested that women who metabolize a larger proportion of their natural estrogen via the 16%-hydroxy pathway may be at significantly elevated risk of breast cancer compared to women who metabolize proportionally more estrogen via the 2-hydroxy pathway. This study evaluates whether the ratios of 16a-OHEl to 2-OHEl are higher in urine of premenopausal women at 'high' than at 'low' familiar risk of breast cancer; and whether the ratio is elevated in cases independent of total urinary estrone (E1), estradiol (E2) and estriol (E3). Early morning urine samples are collected from 100 premenopausal women at 'high' and 100 premenopausal women at 'low' risk of breast cancer. All subjects are sisters or daughters of subjects participating in one of three case-control studies of breast cancer at our institution. Five estrogen metabolites in urine are determined: 1 6a-OHE 1, OHE 1, El, E2 and E3 conjugates. The data collection is in progress.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1995
Accession Number
ADA306474

Entities

People

  • Giske Ursin

Organizations

  • University of Southern California

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Anesthesia
  • Biomedical Research
  • Breast Cancer
  • California
  • Cancer
  • Chemical Compounds
  • Chemistry
  • Classification
  • Diseases And Disorders
  • Estrogens
  • Fatty Acids
  • Genetics
  • Materials
  • Metabolism
  • Metabolites
  • Neoplasms

Readers

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