Attenuated VEE Vaccine Vectors Expressing HIV Immunogens.
Abstract
A series of expression vectors based on attenuated vaccine strains of Venezuelan equine encephalitis virus (VEE) have been constructed with the ultimate goal of expressing immunizing antigens derived from HIV- 1 in vivo, thus protecting against subsequent exposure to HIV. To that end we have constructed four such vectors and expressed HIV-l matrixicapsid, gpi6O and gpl2o in cell culture and in rodent models. Analogous constructs expressing SIV immunogens also have been generated. These are being evaluated in rodent models in preparations for primate trials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1995
- Accession Number
- ADA307632
Entities
People
- Robert E. Johnston
Organizations
- University of North Carolina at Chapel Hill