Inhalation Uptake and Metabolism of Halon 1301 Replacement Candidates, HFC-227 ea, HFC-125, and FC-218.
Abstract
The purpose of this study was to measure the tissue to air partition coefficients and to describe the uptake and distribution kinetics of bromotrifluoromethane's (Halon 1301) proposed replacement chemicals HFC-227ea, HFC-125, and FC-218. Parallel information pertaining to Halon 1301 and CF(3)I can be found in AL/OE-TR-1994-0068. Tissue to air partition coefficients were determined using the vial equilibration method (Gargas et al., 1989). Inhalation pharmacokinetics for all Halon 1301 replacements were determined experimentally in Fischer 344 (F-344) male rats via a closed chamber recirculating gas uptake methods (Gargas et al., 1986). A physiologically-based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these experiments. Using these techniques, no metabolism of these chemicals were detected in Fischer 344 rats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1995
- Accession Number
- ADA308304
Entities
People
- G. W. Jepson
- J. R. Creech
- R. J. Williams
- R. K. Black
- S. K. Neurath
Organizations
- Armstrong Laboratory